4CPS-079 Impact of antibiotic use optimisation programme audits on the use of carbapenems in our hospital
Year: 2025
Type: conference-paper
Abstract: Background and Importance Antibiotic Use Optimisation Programmes (AUP) are essential for combating the antibiotic crisis and microbial resistance. They aim to improve clinical outcomes, reduce side effects, and ensure cost-effective treatments. In 2022, our centre noted an increase in carbapenem antibiotic consumption, indicating a critical area for improvement when compared to similar hospitals. Aim and Objectives This study primarily seeks to evaluate the impact of AUP team interventions on carbapenem usage in our hospital, while also assessing the acceptance of the team’s recommendations by healthcare staff. Material and Methods This descriptive study examined audits conducted by the AUP team on carbapenem prescriptions lasting seven or more days, a timeframe after which many prescriptions can be de-escalated or discontinued. The study covered June to December 2023, utilising a pseudo-anonymised database for data collection from the HCIS medical history programme and the Athos management programme. The obtained data were compared with the previous semester’s findings. Various interventions, including escalation, de-escalation, and suspension, were implemented, and tools were provided to physicians through personal interviews to address similar cases. Results A total of 143 audits were performed. In most of the interventions (78.7%) antibiotic discontinuation was proposed, while in 21.3% de-escalation or change of antibiotic was proposed. The total degree of acceptance of the recommendations was 52.4%, although it varied widely according to the service, being higher in Traumatology (100%) and General Surgery (85%). On the other hand, Internal Medicine (36%) and Medical Oncology (25%) had the lowest degree of acceptance. Carbapenemics consumption was measured in DDD/100 stays. In the first half of 2023, the calculated DDD/100 stays was 7.94. After the AUP team’s action, in the second semester the DDD/100 stays was 6.5, indicating that carbapenemics consumption was reduced by 18%. Conclusion and Relevance The implementation of a AUP team in our hospital has had a positive impact on the prescription of carbapenemics, especially by decreasing its use. Better utilisation of these broad-spectrum antibiotics has been achieved, improving the quality of prescribing. It would be necessary to use multimodal measures to evaluate the clinical and ecological impact of the measures implemented, as well as statistical regression analyses to determine whether there has been a significant change in trend. References and/or Acknowledgements Conflict of Interest No conflict of interest
Authors: P Villacorta, M Sánchez, T Mata, MI Serrano, S García, S Heinz, P Granda, ÁM Yuste, MH Gonzalo
Institution: Hospital Central de la Defensa Gómez Ulla
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4408375756