4CPS-030 Patient-reported outcomes in interstitial lung disease and adherence to antifibrotic therapy
Year: 2025
Type: conference-paper
Study design: Observational Study
Abstract: Background and Importance Interstitial lung disease (ILD) is a debilitating disease and there are limited therapies which focus on slowing disease progression. Aim and Objectives To describe Patient-Reported Outcomes (PROs) on ILD and analyse the relationship with disease perception, satisfaction with antifibrotic therapy and adherence. Material and Methods Retrospective, observational, descriptive study conducted by telephone surveys during February-March 2024 among patients with antifibrotic therapy. Surveys included: perception of disease, satisfaction with treatment (SATMED-Q survey) and Morisky-Green test (MG). Other variables collected were sex, age, education, type of ILD, duration of treatment and adherence (dispensing records in Farmatools (optimal >80%)). Results 46 patients were included. 85% were male, median age 72 years. 13% had no education, 33% primary, 30% secondary and 24% university education. 41% were diagnosed with ILD with usual interstitial pneumonia pattern, 30% with idiopathic pulmonary fibrosis, 11% with ILD associated with autoimmune diseases and the rest with other ILDs. 85% were treated with nintedanib, 15% with pirfenidone. Median treatment duration: 13 months. Regarding perception of the disease 52% felt that ILD affected their daily life, 54% felt physically limited, 35% felt emotionally limited, 32% felt their social life was affected, 41% felt their sleep quality was affected and 48% of patients had stopped performing daily activities. 67% had an adverse event, mainly gastrointestinal. 20% of patients had their dose reduced. According to the SATMED-Q, the mean satisfaction with treatment was 74%. The MG test showed 30% non-adherence (NA), of which 85% was due to forgetting to take the medicine. According to dispensing records, 92% patients were adherent (A). Correlation with the MG test was low in NAs (only 14% detected) but high in As (91%). Of the 31 patients who had adverse events, 71% were adherent according to the MG test compared to 67% of the 15 patients who had no adverse effects. Conclusion and Relevance ILD is a disabling disease which make patients committed to their treatment despite the side effects. No relationship was found between education, adverse events or SATMED-Q score and adherence The most important factor associated with NA is forgetting to take medication; it would be important to use reminders in this population. References and/or Acknowledgements Conflict of Interest No conflict of interest
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4408376304