4CPS-213 Impact of the antimicrobial stewardship programme on antibiotic consumption in two internal medicine units
Year: 2025
Type: conference-paper
Study design: Observational Study
Abstract: Background and Importance Antimicrobial Stewardship Programs (ASPs) are essential to improve clinical outcomes and reduce antimicrobial resistance, a growing public health issue. In the current context, their implementation is critical. Aim and Objectives Compare antimicrobial consumption (DDD per 100 bed days) between two Internal Medicine units (A vs.B) of the same healthcare complex, but physically separated. Unit-A has the presence of an ASPs team. Material and Methods Observational and retrospective study conducted in a public tertiary care hospital with 888-beds (average length of stay =6.6 days; occupancy rate =70.3%). Two Internal Medicine units (A vs.B) were analysed with the following characteristics: beds=174 (vs.94); average length of stay=8.7 days (vs.8.4); occupancy rate=70% (vs.84.88%), mortality rate per number of admissions=11.9% (vs.14.2%). Antimicrobial consumption (groups J01-J04) was analysed (years: 2021–2023). Consumption data were obtained from the Pharmacy Management System and hospitalisation indicators from the Admissions Service. The ATC/DDD system of the World Health Organization was adopted, using DDD values established for 2023. The measure used was DDD/100-bed days, and de consumption trend was compared; the differences between the two units were evaluated using Chi-squared test (p-value=0, 1). Results Antimicrobials overall consumption (DDD/100B) increased in both units, but it was greater in unit-B. Also, the increase by spectrum was more pronounced in B. These differences were significant in overall consumption (p=0.001) and anti-pseudomonal antimicrobials consumption (p=0.078). In 2023, the most commonly used antibacterials (DDD/100B Unit-A vs.Unit-B) were: ceftriaxone (25,87 vs.26,27), piperaciclin/tazobactam (12,12 vs.12,11), amoxicilin/clavulanic acid (8,71 vs.13,81) and levofloxacin (6,39 vs.9,23). Conclusion and Relevance There are quantitative and qualitative differences in the use of antimicrobials between the units, with more appropriate use in unit-A. Although the origin of these differences may be multifactorial, the presence of a multidisciplinary ASPs team (Unit-A) appears to have a positive impact on optimising antimicrobial consumption. It is essential to implement ASPs in all hospital units to improve clinical outcomes, ensure cost-effective and safe use, and reduce antimicrobial resistance. References and/or Acknowledgements WHO Collaborating Centre for Drug Statistics Methodology. Available from https://www.whocc.no/atc_ddd_methodology/who_collaborating_centre/ Conflict of Interest No conflict of interest
Authors: A Fernández Vázquez, M Saez Villafañe, D Ozcoidi Idoate, R Varela Fernández, X Casas Fernández, M Flores Fernández, M Barba Llacer, JC Sáez Hortelano, L Mira Bayón, J Ayala Alvarez-Canal, JJ Ortiz de Ubina
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4408376729