5PSQ-141 Impact of cabotegarvir and rilpivirine long-acting in quality of life of subjects in a real-world setting: preliminary data
Year: 2025
Type: conference-paper
Study design: Observational Study
Abstract: Background and Importance Long-acting (LA) injectable therapy with cabotegravir (CAB) and rilpivirine (RPV) may improve quality of life. General health was assessed in clinical trials about LA CAB+RPV using the 12-Item Short Form Health Survey (SF-12) questionnaire, that includes norm-based physical and mental component scores (PCS and MCS) ranging from 0 to 100 points, with higher scores indicating better health.1 Aim and Objectives To describe the quality of life, according to the SF-12 questionnaire, of patients in treatment with LA CAB+RPV in a real-world setting. Material and Methods We conducted a multicentre, non-controlled, retrospective and prospective study (relativity cohort) in HIV patients on treatment with LA CAB+RPV. Patients could answer the SF-12 questionnaire between 9–14 months of treatment via electronic devices using a QR code provided. The data were collected on the RedCap platform for subsequent analysis. Results The study included 205 patients from 13 hospitals in Spain. Median age of patients is 46.0 (38.2, 55.4) years and 88.7% males. The current follow-up duration is 13.1 (11.0, 15.1) months. At the time of answering the questionnaire patients had a median score in SF-12 of 55.5 (52.4, 57.2) in PCS and 53.1 (44.7, 57.8) in MCS. 189 (92.2%) of the patients considered that at the time of the study their health status was good, very good or excellent. 178 (86.8%) patients had no limitations for moderate activities, 187 (91.2%) patients answered that they continued with their daily activities and 174 (84.9%) patients that they had no pain that hindered their usual work. 168 (82.0%) patients responded that their emotional state of health had not prevented them from carrying out their daily activities as carefully as usual(MOU1). 155 (75.6%) patients had no physical or emotional difficulties in continuing their social activities. Conclusion and Relevance The PCS and MCS scores are similar to those described in the healthy US population (mean of 50). Our data suggest that patients with LA CAB+RPV have a good state of physical and mental health. Longer follow-up in more patients is needed to obtain more consistent data. References and/or Acknowledgements AIDS and Behaviour, 24(12), 3533–3544. https://doi.org/10.1007/s10461-020-02929-8 Conflict of Interest No conflict of interest
Authors: S Arnaiz Diez, L Sanchez Luque, R Pedrero Tome, M Espinosa, M Montes, J Troya, E Bernal, P Mascarell, JE Losa Garcia, F Tejerina Picado
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4408377104