Work

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Year: 2025

Type: article

Abstract: ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and integration of grafted cells. Biomaterials have emerged as an attractive solution to this problem by providing a protective microenvironment to deliver cells to injured tissues. The design of biomaterials compatible with nervous tissues to promote tissue repair and functional recovery is a focus of neural tissue engineering. A wealth of research has explored different materials and architectures in combination with bioactive cues to promote neural and glial cell growth and maturation. After a brief presentation of biomaterial strategies and cell sources, we review the in vivo evidences about the efficacy of biomaterial and stem cell cotransplantation in (i) enhancing trophic effects, (ii) increasing cell integration, and (iii) achieving functional recovery in preclinical models of stroke, traumatic brain injury, Parkinson's disease, and spinal cord injury. Furthermore, a comprehensive perspective was offered regarding the specific implementation tactics, obstacles, and development orientations of employing biomaterials as critical support to promote cell transplantation.

Source: Aggregate

DOI: 10.1002/agt2.70022

Authors: Yun Tang, Alice Le Friec, Menglin Chen, Di Sun

Institutions: Shanghai Jiao Tong University, Shanghai Sixth People's Hospital, Aarhus University

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,000