Work

Synthetic Strategy of RITA Drug Enabled by N‐Heterocylic Carbene via 1,4‐Synthon Formation and DFT Studies**

Year: 2025

Type: article

Abstract: This paper describes an efficient and convenient procedure to synthesize substituted symmetrical 1,4‐butanedione derivatives via a double Stetter reaction using divinyl sulfone and corresponding aldehydes with broad substrate scopes. A theoretical investigation and DFT calculation were studied to form 1,4‐di(thiophene‐2‐yl)butane‐1,4‐dione from thiophene‐2‐carboxaldehyde and the mechanism was proposed. A substrate 1,4‐di(thiophene‐2‐yl)butane‐1,4‐dione was subjected to Paal Knorr furan synthesis, Vilsmeier‐Haack di‐formylation followed by sodium borohydride reduction delivered the RITA drug.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.202400761

Authors: Nithya Murugesh, Saravanan Saranya, Packirisamy Kuzhalmozhi Madarasi, Rekha Muthuvel, Ramasamy Karvembu, Seenuvasan Vedachalam

Institutions: National Institute of Technology Tiruchirappalli, National Institute of Technology, Puducherry

Language: English

Topic: N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Science and Engineering Research Board

Award: G7920080009