Work

Gastric mucosal CD8+TRM cells are recruited through CXCR5-CXCL13 axis in Helicobacter pylori infected subjects

Year: 2025

Type: article

Abstract: Gastric mucosal CD8 + tissue-resident memory T (CD8 + T RM ) cells are increased in Helicobacter pylori ( H. pylori ) infected subjects, but the characteristics and chemotactic mechanism of CD8 + T RM cells remain unknown. We demonstrated that C-X-C chemokine receptor 5 (CXCR5) was upregulated on gastric mucosal CD8 + T RM cells, and gastric CXCL13 was dominantly secreted by dendritic cells and macrophages in H. pylori infected subjects. Gastric mucosal CD8 + T RM cells from CagA+ H. pylori infected subjects was increased and could secrete more IFN-γ and TNF-α to engage in local immune response. The number of gastric mucosal CD8 + T RM cells and the expression of CXCL13 was elevated in H. pylori infected individuals with the development of gastric diseases. In conclusion, gastric mucosal CD8 + T RM cells are increased from CagA+ H. pylori infected subjects and could be recruited through CXCL13-CXCR5 axis, which mainly release IFN-γ and TNF-α in H. pylori related immune response. • Gastric mucosal CD8 + T RM cells are recruited by CXCL13-CXCR5 in the H. pylori infected. • Gastric mucosal CD8 + T RM cells in the CagA+ H. pylori infected release more cytokines. • Gastric CXCL13 is secreted by B cells, DCs and Mφ in H. pylori infected subjects. • Gastric CD8 + T RM cells raise as the proceed of H. pylori related gastric diseases.

Source: Cytokine

DOI: 10.1016/j.cyto.2025.156904