Breaking down KRAS: small-molecule degraders for cancer therapy
Year: 2025
Type: article
Abstract: In their recently published study in Science , Popow and colleagues developed a proteolysis-targeting chimera (PROTAC) for the in vivo degradation of several oncogenic KRAS variants. 1 Leveraging detailed biophysical analyses and crystal structures of ternary complexes of candidate ligands for KRAS and the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex, they designed a small molecule capable of potently and selectively targeting 13 of the 17 most common KRAS mutants.
Authors: Tina Kos, Dieter Saur
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,790
Awards: G1526559182, G1796449573, Inflammatorische Signalwege in Subtypen von intestinalen Tumoren, Mechanistische Aufklärung und therapeutische Blockade von inflammatorischen Signalwegen in PankreaskarzinomSubtypen, G6366907205, Duale Rekombinasesysteme zur Entwicklung von Kombinationstherapien für das Pankreaskarzinom, G6663943073, Genomweite transkriptionelle Netzwerkanalyse von pharmakologischen Hochdurchsatzscreens im Pankreaskarzinom, G7195677553, G7531771280
OpenAlex ID: W4408394991