Ethanol whole plant extract of Ochna afzelii Theales (Ochnaceae) ameliorates anaphylactic inflammation in wistar rats
Year: 2024
Type: article
Abstract: Research has shown that Ochna afzelii commonly known as African Plane or African Ochna or Afzel’s ochna is a rich source of complex flavonoids which are known to possess anti-inflammatory activity. This study aimed to investigate the immune-mediated anti-inflammatory activity of the ethanol whole plant extract of O. afzelii in rats. The immune-mediated anti-inflammatory activity was evaluated using egg albumin-induced active paw anaphylaxis model in rats; and histamine-induced paw edema model in Wistar rats For each of the models, thirty (30) Wistar rats weighing 150 ‐ 200 g were divided into five groups containing six (6) rats each and were orally administered with single doses of the following treatments: a negative control group (distilled water, 10 ml/kg), a positive control group (dexamethasone, 0.27 mg/kg), and three test groups receiving 250, 500, and 1000 mg/kg of ethanol whole plant extract of Ochna afzelii respectively. The extract at the dose of 250mg/kg significantly (p˂0.05) inhibited paw inflammation at 2 hrs post antigen exposure compared to1 hr post antigen exposure of the same 250mg/kg group (within group comparison). The extract at 500 and 1000 mg/kg also significantly (p˂0.05) reduced paw edema induced by histamine, with the 1000 mg/kg dose showing effects comparable to dexamethasone. Ethanol whole plant extract of O. afzelii possess immune mediated anti-inflammatory activity in Wistar rats and this justifies the traditional use of the plant in management of anaphylactic disorders.
DOI: 10.54117/jcbr.v4i6.3
Authors: Ibrahim Mu'azzamu Aliyu, Bamaiyi Rikum Isaac, Abdulaziz Muhammed, ZakiyyahYakubu Yahaya Ibrahim
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4408407200