Regional variations in corneal oedema during open‐eye fenestrated scleral lens wear
Year: 2025
Type: article
Abstract: PURPOSE: To compare the magnitude of central, mid-peripheral and peripheral stromal corneal oedema induced during short-term fenestrated and non-fenestrated scleral lens wear. METHODS: ) (mmHg)]) in one eye under open-eye conditions for 90 min on two separate days. Scleral lens thickness, fluid reservoir thickness and stromal corneal oedema were measured using high-resolution optical coherence tomography. Stromal oedema was quantified across the central (0-2.5 mm from the corneal apex), mid-peripheral (-3.0 to -1.0 mm from the scleral spur) and peripheral (-1.0 to 0 mm from the scleral spur) cornea with the lens in situ. The magnitude of oedema was corrected based on variations in fluid reservoir thickness between the lens conditions. RESULTS: There was a significant effect of lens type (p = 0.04) on stromal oedema, with less oedema observed with the fenestrated (0.36 ± 0.45%) compared to the non-fenestrated lenses (1.24 ± 0.27%), averaged across all corneal locations. A significant lens type by corneal location interaction was also observed (p = 0.05), with less oedema observed in the peripheral region for the fenestrated (-0.15 ± 0.98%) compared to the non-fenestrated lenses (1.81 ± 0.57%) (p = 0.048). A fenestration location by corneal location interaction was also observed (p = 0.02), indicating a greater reduction in oedema closer to the fenestration. CONCLUSIONS: Central and mid-peripheral stromal oedema was similar during fenestrated and non-fenestrated lens wear; however, fenestrated lenses displayed significantly less oedema in the peripheral cornea. This is most likely due to increased oxygen delivery in proximity to the fenestration.
DOI: 10.1111/opo.13489
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,050
OpenAlex ID: W4408415944