Unraveling the Genetic Basis of Bipolar Disorder: Implications for Future Research and Clinical Practice
Year: 2025
Type: article
Abstract: This paper explores the genetic underpinnings of bipolar disorder (BD) to enhance understanding and inform clinical practice. It aims to examine the hereditary components of BD, identify specific genetic markers, and discuss their implications for diagnosis, treatment, and prevention. The study synthesizes findings from family and twin studies, molecular genetics research, genome-wide association studies (GWAS), and epigenetic analyses. It also reviews the role of genetic markers such as CACNA1C and ANK3 and their impact on neurobiological mechanisms associated with BD.The analysis confirms a strong genetic component in BD, with family and twin studies showing significant heritability. Specific genetic markers linked to neurotransmitter signaling and synaptic function are identified. The paper also discusses the role of voltage-gated calcium channels and synaptic function in BD pathophysiology, as well as the influence of epigenetic factors and gene-environment interactions.The findings underscore the importance of integrating genetic data into clinical practice for personalized treatment strategies. Future research should focus on rare genetic variants, deeper exploration of neurobiological mechanisms, and the challenges of translating genetic insights into clinical applications.
Source: Theoretical and Natural Science
Author: Aichen Long
Institution: National University of Malaysia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4408416468