Work

Base‐Catalyzed Remote Hydrogermylation of Olefins

Year: 2025

Type: article

Abstract: Although remote functionalization has emerged as a powerful strategy for modifying unactivated sites that are traditionally challenging to functionalize, there has been no remote hydrogermylation known to date. This work reports the first remote hydrogermylation of alkenes, achieved through a rare base-catalyzed approach-completely free of added transition metal catalysts. The methodology is operationally simple, versatile, and capable of achieving up to 8-carbon chain walks, overcoming the previous two-carbon limit of base-mediated processes.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.202503573

Authors: Eric Ahrweiler, Aymane Selmani, Franziska Schoenebeck

Institution: RWTH Aachen University

Language: English

Topic: Organoselenium and organotellurium chemistry

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $5,510

Funder: RWTH Aachen University