Work

ZNF667 alleviates the inflammatory damage in intervertebral disc degeneration via inhibiting NF-κB signaling pathway.

Year: 2024

Type: article

Abstract: OBJECTIVES: With the aging population, the incidence of intervertebral disc degeneration (IDD) is increasing every year. The pathogenesis of IDD is complex, and there are currently no effective treatment options. This study aims to investigate the specific function and underlying mechanism of zinc finger protein 667 (ZNF667) in the inflammatory damage of nucleus pulposus cells in IDD. METHODS: mRNA expression, and Western blotting assessed protein expression levels of ZNF667, myeloid differentiation factor 88 (MyD88), P65, and phosphorylated P65 (p-P65). RESULTS: <0.05). CONCLUSIONS: ZNF667 can alleviate nucleus pulposus cell apoptosis and inflammatory responses by inhibiting the NF-κB signaling pathway, thereby exerting a protective effect on intervertebral discs. This finding not only provides new insights into the pathogenesis of IDD but also suggests a potential therapeutic target for its treatment.

Source: PubMed

DOI: 10.11817/j.issn.1672-7347.2024.240122

Authors: Hua Zhong, Lebin Guo, Yan Yang, Chenjun Tian, Fusheng Liu, Bowen Zheng

Institutions: Hunan University of Traditional Chinese Medicine, Central South University, Second Xiangya Hospital of Central South University, Xiangya Hospital Central South University

Language: English

Topic: Spine and Intervertebral Disc Pathology

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4408420853