Work

5-HT1AR agonist alleviates presurgical prolonged sleep deprivation-induced postsurgical pain in adolescent mice.

Year: 2024

Type: article

Abstract: OBJECTIVES: R) regulates the excitation/inhibition (E/I) balance in the dorsal horn to modulate postoperative chronic pain induced by SD in adolescent mice. METHODS: -methyl-D-aspartic acid receptor 1 (NR1), phosphorylated NR1 (p-NR1), vesicular glutamate transporter 1 (VGLUT1), gephyrin, glutamic acid decarboxylase 67 (GAD67), vesicular gamma-aminobutyric acid transporter (VGAT), ERK, p-ERK, calmodulin-dependent protein kinase II (CaMKⅡ), phosphorylated CaMKⅡ (p-CaMKⅡ), cAMP- response element-binding protein (CREB), and phosphorylated CREB (p-CREB) in the dorsal horn. RESULTS: <0.05). CONCLUSIONS: R agonist alleviates postoperative chronic pain induced by SD in adolescent mice by inhibiting the CaMKⅡ-ERK-CREB signaling pathway, thereby correcting the E/I imbalance in the spinal dorsal horn.

Source: PubMed

DOI: 10.11817/j.issn.1672-7347.2024.240499

Authors: Wei Zhu, Xuan Xu, Rui Xu, Yulin Huang, Zhengliang Ma

Institutions: Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing University

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4408420903