Year: 2025
Type: article
Abstract: Caloric restriction (CR) is a dietary intervention that delays the onset of age-related diseases and enhances survival in diverse organisms, and although changes in adipose tissues have been implicated in the beneficial effects of CR, the molecular details are unknown. Here we show shared and depot-specific adaptations to life-long CR in subcutaneous and visceral adipose depots taken from advanced age male rhesus monkeys. Differential gene expression and pathway analysis identified key differences between the depots in metabolic, immune, and inflammatory pathways. In response to CR, RNA processing and proteostasis-related pathways were enriched in both depots, but changes in metabolic, growth, and inflammatory pathways were depot-specific. Commonalities and differences that distinguish adipose depots are shared among monkeys and humans, and the response to CR is highly conserved. These data reveal depot-specificity in adipose tissue adaptation that likely reflects differences in function and contribution to age-related disease vulnerability.
Source: Aging Cell
DOI: 10.1111/acel.70254
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,790
Awards: EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION, EXTRAMURAL REGIONAL FACILITIES CONSTRUCTION, Caloric Restriction and Aging in Rhesus Monkeys, Dietary Restriction and Aging in Rhesus Monkeys, G9000300278, Wisconsin National Primate Research Center Support, UW Comprehensive Cancer Center Support, Biology of Aging and Age-Related Diseases, Molecular Networks in Aging and Caloric Restriction in Rhesus Monkeys, Wisconsin Nathan Shock Center, Wisconsin National Primate Research Center Support
OpenAlex ID: W4414782333