Work

(Spiro) phenanthrenes and bibenzyls in Dendrobium chrysotoxum Lindl and their cytotoxic as well as anti-pulmonary fibrosis activities

Year: 2025

Type: article

Abstract: The stems of Dendrobium chrysotoxum Lindl is used as medicinal herb and for nutraceutical beverages and functional food products. In order to fully understand the compounds in the stems of D. chrysotoxum Lindl, a comprehensive study was carried out. A total of 20 undescribed compounds (1−20) along with 40 known ones (21−60) were isolated. The unreported compounds are 7 spirophenanthrenes (1−7), 4 diphenanthrenes (8−11), 1 9,10-dihydrophenanthrene derivative (12), 1 phenanthropyran (13), 2 monophenanthrenes (14 and 15), 1 dimeric bibenzyl (16), and 3 bibenzyls (17−20). Their structures were elucidated on the basis of spectroscopic data. Six compounds 1b, 3b, 4a, 4b, 8, and 16 possess cytotoxic activity against HCCLM3 cancer cells, with IC50 values of 1.68 μM to 6.60 μM. Compounds 10, 15, and fimbriadimerbibenzyl D display significant anti-pulmonary fibrosis with IC50 values of 1.82 ± 0.02 μM to 3.68 ± 0.03 μM.

Source: Phytochemistry

DOI: 10.1016/j.phytochem.2025.114482