Grape Juice Minimizes Inflammation and Reduces Hospitalization Time in Patients With Covid-19
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Inflammation and oxidative stress are the main mortality mechanisms caused by SARS-CoV-19. Grape juice has anti-inflammatory and antioxidant properties, which are believed to be beneficial in treating COVID-19. This randomized clinical trial evaluated the impact of grape juice supplementation in the treatment of patients with COVID-19. Thirty-six patients were randomized to the grape juice supplementation group (GJG, n = 20; 10 ml/kg/day) or the control group (CG, n = 16), which received conventional COVID-19 treatment protocols. Blood samples were collected at admission and discharge for analysis of oxidative stress markers. CBC, C-reactive protein levels, electrolytes and markers of renal function were obtained from medical records. Handgrip strength was also measured to assess muscle strength. The GJG presented significantly lower levels of C-reactive protein compared to the CG (16.35 ± 26.81 vs 56.51 ± 73.29, respectively) with an intragroup decrease in C-reactive protein after the procedures (p = 0.010). The strength of the non-dominant hand in the GJG improved in relation to pre-intervention levels and in the CG after the procedures (p < 0.05), there was a significantly shorter hospital stay for the GJG compared to the CG (6.85 ± 3 .16 vs 9.94 ± 5.69 days, respectively). The addition of grape juice during COVID-19 treatment reduced inflammation levels and length of hospital stay and increased upper limb functional strength in COVID-19 patients. Clinical trial registration: RBR-4bcp54k
Authors: Crislane de Moura Costa, Alexandre Sergio Silva, Aislan Erick Pereira de Sousa, Rayane Carvalho de Moura, Valmir Oliveira Silvino, Aline Camarão Telles Biasoto, Débora Santos Lula Barros, Esmeralda Maria Lustosa Barros, Leonardo da Rocha Sousa, Joyce Lopes Macedo, Lais Lima de Castro Abreu, Maria do Carmo de Carvalho e Martins, Guilherme Loureiro Werneck, Davyson de Lima Moreira, Regis Bernardo Brandim Gomes, Marcos Antonio Pereira dos Santos
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408425576