Work

Biomarkers of bipolar disorder in omics and neuroimaging

Year: 2025

Type: article

Abstract: Bipolar disorder (BD) affects 1% of the global population. BD is a group of chronic psychiatric disorders characterized by recurrent manic or hypomanic episodes that may alternate with depressive episodes. Given the current diagnostic modalities, accurately diagnosing BD, particularly distinguishing it from unipolar depression (UD), is challenging. Biomarkers have emerged as potent instruments for establishing objective diagnostic criteria for BD, and their identification, which reflects the pathophysiological processes of BD, can facilitate the precise diagnosis of the disorder. In this review, the search terms “BD” and “diagnosis” or “biomarker” were used as the key search syntax. In total, 110 studies were included. This review systematically examines the research in the field and summarizes current studies on biomarkers of BD in omics and neuroimaging. We hope that this review will benefit research aimed at establishing objective diagnostic criteria for BD and developing novel therapeutic interventions. • Biomarkers may provide objective diagnostic criteria for bipolar disorder (BD). • Omics and neuroimaging may advance biomarker research for BD. • We conducted an overview of current biomarkers for BD. • Genomic, transcriptomic, proteomic, metabolomic, and neuroimaging markers are proposed. • Currently no biomarker has been definitely identified, but some hold promise.

Source: Journal of Pharmaceutical Analysis

DOI: 10.1016/j.jpha.2025.101264

Authors: Donglin He, Jingzhi Yang, Zuowei Wang, Xin Dong

Institutions: Shanghai University, Shanghai Mental Health Center

Language: English

Topic: Bipolar Disorder and Treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950