Work

Successful management of TSH-secreting adenoma misdiagnosed as hypothyroidism in 65-year-old male: A case report

Year: 2025

Type: article

Abstract: INTRODUCTION: Thyrotropin-secreting adenoma (TSHoma) is a rare functional pituitary tumor, accounting for less than 3 % of all pituitary tumors, characterized by central hyperthyroidism and inappropriate TSH secretion. PRESENTATION OF CASE: We present a case of a 65-year-old man with a history of unresponsive hypothyroidism, diagnosed with a pituitary tumor through MRI and CT scans. Following partial tumor resection, histopathological examination confirmed a benign TSHoma. The patient was discharged in stable condition after three days, receiving long-term octreotide injections and propranolol without complications. DISCUSSION: TSHomas, resulting from abnormal growth of TSH-producing pituitary cells, pose diagnostic challenges and are often misdiagnosed. Trans-Sphenoidal surgery is the standard treatment, and long-acting somatostatin analogs like octreotide can effectively restore normal thyroid function in over 90 % of patients. CONCLUSION: This report emphasizes the need to consider TSHoma as a potential cause that may be initially overlooked, highlighting the diagnostic and management challenges of this rare condition.

Source: International Journal of Surgery Case Reports

DOI: 10.1016/j.ijscr.2025.111153

Authors: Ahmed Sheikh Sobeh, Kenana tawashi, Ayham Qatza, Shahama Al-shami, Wardan A. Tamer

Institution: Hama University

Language: English

Topic: Pituitary Gland Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,090