Sex Hormones and Heart Failure Risk
Year: 2025
Type: article
Abstract: Heart failure (HF) is a significant cause of morbidity and mortality. Although there are inconsistencies, epidemiological studies have implicated sex hormones (SHs) in pathways that are linked to HF. The age-related decline in SH levels causes physiological changes that differentially impact HF risk in both sexes. Conversely, SHs are tightly regulated by complex feedback loops that become disrupted in chronic HF to create a vicious cycle that further worsens the HF syndrome. By altering the androgenic balance, SHs exert variable effects that could impact HF risk in men and women. Further studies are needed to clarify whether measurement of SH levels can identify future HF patients for early intervention, as well as HF patients who may benefit from more intensive treatments.
Source: JACC Advances
Institutions: University of California Davis Medical Center, University of California, Davis, Texas Tech University, Texas Tech University Health Sciences Center, The University of Texas Southwestern Medical Center, Advocate Christ Medical Center, Harvard University, Massachusetts General Hospital, Indiana University Indianapolis, Mayo Clinic, Creighton University, Cleveland Clinic, Johns Hopkins University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,936
Awards: G2137349462, Health-related social needs and the risk of hypertension in young adult and early midlife women: The impact of pregnancy, Clonal Hematopoiesis and Cardiovascular Disease in Women with Premature Menopause, Clonal hematopoiesis as a mediator of cardiovascular disease in women with premature menopause, G954386746
OpenAlex ID: W4408439817