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Exploring the Chemical Space of Paenibacillus NRPs and Discovery of Paenilipoheptin B

Year: 2025
Type: article
Abstract: A combination of genomic and metabolomic analyses paired with molecular networking was applied to a collection of Paenibacillus spp. to identify the producers of a little-studied class of lipopeptides known as paenilipoheptins. Mass spectrometry and NMR spectroscopy allowed revision of the structure of previously reported paenilipoheptin A and elucidation of the structure of novel paenilipoheptin B.
DOI: 10.1021/acs.orglett.5c00231
Authors: Nataliia V. Machushynets, Vladyslav Lysenko, Chao Du, Cornelis J. Slingerland, Somayah S. Elsayed, Mark R. Liles, Nathaniel I. Martin, Gilles P. van Wezel
Language: English
Subfield: Pharmacology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,500
OpenAlex ID: W4408451242
FWCI: 2.406
Cites: 21
Cited by: 6
Related to: 10