The Addition of Low‐Dose Lidocaine and Triamcinolone Reduces the Adverse Effects of 2‐Deoxycholate Injection Without Affecting the Long‐Term Results
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: INTRODUCTION: The study investigates the efficacy of combining low-dose triamcinolone acetonide (TAC) and lidocaine with deoxycholic acid (DCA) injections to reduce adverse effects (AEs) without compromising long-term results. METHODS: A double-blind, randomized trial was conducted with 15 subjects, divided into a control group (DCA with lidocaine) and an intervention group (DCA with low-dose TAC and lidocaine). The primary outcomes measured were injection pain, swelling, and submental fat reduction. RESULTS: Results indicated that the intervention group experienced significantly reduced pain and swelling compared to the control group. Both groups showed similar efficacy in submental fat reduction, with the intervention group demonstrating a greater mean volumetric loss. CONCLUSION: The study concludes that the addition of low-dose TAC and lidocaine to DCA injections is a safe and effective method to enhance patient comfort and treatment outcomes without inducing steroid-related side effects.
Source: Journal of Cosmetic Dermatology
DOI: 10.1111/jocd.70072
Authors: Shealinna Ge, Robert A. Weiss, Laura Schilling, Claire M. Noell
Institution: Maryland Dermatology Laser Skin and Vein Institute
Language: English
Topic: Body Contouring and Surgery
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,020
OpenAlex ID: W4408456642