Work

Sequential two-step, one-pot microwave-assisted Urech synthesis of 5-monosubstituted hydantoins from L-amino acids in water

Year: 2025

Type: article

Abstract: The hydantoin scaffold is renowned for its wide-ranging biological activities, including antibacterial, antiviral, anticancer, anti-inflammatory, and anticonvulsant effects. In this study, we present an innovative, sustainable approach to synthesizing hydantoins ( H2a – j ) directly from amino acids. This method employs a column chromatography-free, two-step, one-pot microwave-assisted synthesis that delivers hydantoins in yields ranging from 34% to 89%. The protocol demonstrates exceptional functional group tolerance, accommodating phenyl, aliphatic, phenol, alcohol, heterocyclic, and sulfide groups. This scalable, rapid, and eco-friendly strategy offers a promising avenue for the efficient synthesis of hydantoins, aligning with green chemistry principles and expanding the accessibility of these bioactive compounds for pharmaceutical applications.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.21.46

Authors: Wei-Jin Chang, Sook Yee Liew, Thomas Kurz, Siow-Ping Tan

Institutions: Tunku Abdul Rahman University of Management and Technology, University of Malaya, Heinrich Heine University Düsseldorf

Language: English

Topic: Microwave-Assisted Synthesis and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Tunku Abdul Rahman University of Management and Technology

Award: G7903956910