Study of the effect of mechanical properties of materials on cell behaviour based on molecular dynamics simulations
Year: 2025
Type: article
Abstract: This study delves into the mechanical properties of polycrystalline tantalum nanomaterials with varying grain sizes and their influence on fibroblast behavior, utilizing molecular dynamics simulations. The cutting simulations revealed that tantalum nanomaterials with larger grain sizes exhibit superior mechanical performance. Detailed analyses of stress-strain curves, elastic modulus, and elongation at break further demonstrated that larger grain-sized tantalum nanomaterials possess enhanced toughness and compressive strength, positioning them as promising candidates for biomedical applications. Additionally, cellular experiments evaluated the biological effects of these nanomaterials on fibroblasts, showing that larger grain sizes significantly promote fibroblast proliferation. This highlights their potential in tissue engineering and regenerative medicine. By uncovering the intricate relationship between the mechanical properties of tantalum nanomaterials and cellular responses, this study underscores the critical role of material mechanics in biological applications and provides valuable insights for the future design of advanced biomedical materials.
DOI: 10.62617/mcb1184
Author: Songjie Wu
Institution: Liaoning Institute of Science and Technology
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4408462270