Work

Terapia di successo con cellule CAR-T in un paziente con MCL refrattario con malattia rapidamente progressiva: un caso clinico

Year: 2025

Type: article

Abstract: Mantle cell lymphoma is a rare and aggressive hematologic malignancy characterized by frequent relapses and poor prognosis. Recently, the approval of CAR-T cell therapy has transformed the treatment landscape for relapsed/refractory patients. We report the case of a 52-year-old patient with mantle cell lymphoma who experienced multiple disease relapses. Specifically, the patient showed a rapid and severe progression after treatment with BTK inhibitors in the second line of therapy and was subsequently evaluated for a CAR-T cell therapy program. This case highlights the importance of a multidisciplinary approach, with efficient collaboration optimizing timelines for treatment eligibility, leukapheresis planning, bridge therapy, and CAR-T cell infusion (brexu-cel). The CAR-T treatment was well tolerated, although it was associated with a rare cardiovascular complication, sinus bradycardia, and subsequently, a deep vein thrombosis. Thanks to close collaboration with cardiology specialists, these complications were resolved without sequelae. Post CAR-T cell therapy, the patient achieved complete remission, sustained at 15 months of follow-up.

Source: Recenti Progressi in Medicina

DOI: 10.1701/4460.44568

Authors: Mirko Farina, Alessandro Re

Institutions: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, University of Brescia

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Gilead Sciences