Exploiting divergent mechanisms of trabectedin for bone tumors
Year: 2025
Type: article
Abstract: Trabectedin is a natural product chemotherapeutic isolated from Ecteinascidia turbinata, a turbinate that lives throughout the southeast coast of North America, the Gulf of Mexico, and the Mediterranean Sea.1 Extract from this sea squirt was identified as having anti-cancer activity in the 1960s via National Cancer Institute screening. The chemical structure of one of the compounds in the extract, ET-743 (trabectedin), was elucidated in the 1980s, its crystal structure was obtained in 1992, and it was chemically synthesized in 1996.
Source: Molecular Therapy Oncology
Authors: Zachary P. Tolstyka, Patrick J. Grohar
Institutions: University of Michigan, Michigan Medicine, U-M Rogel Cancer Center
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
OpenAlex ID: W4408473386