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Renin-secreting chromophobe renal cell carcinoma: An uncommon cause of secondary hypertension in a young female

Year: 2025

Type: article

Abstract: Renal cell carcinoma (RCC) is a rare but significant cause of secondary hypertension. Chromophobe RCC represents 5 % of all RCC cases, with renin secretion being even rarer. We report a case of a 32-year-old female with six-month history of uncontrolled hypertension. Laboratory findings showed elevated plasma renin and aldosterone levels. Imaging revealed a large left renal mass. After radical nephrectomy, histopathology confirmed chromophobe RCC. Her blood pressure normalized postoperatively, and she was normotensive at 1-month follow-up. This case underscores the importance of considering renal tumors in hypertensive patients and the role of surgery in achieving favorable outcomes.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2025.103011