Work

Antifungal Evaluation of Benzoxazole and Benzothiazole Derivatives: An In Vitro and In Silico Study

Year: 2025

Type: article

Abstract: The benzoxazoles and benzothiazoles derivatives have a variety of pharmacological activities, such as antimicrobial activity. Thus, in the present study, the antifungal activity of 13 benzoxazole and benzothiazole derivatives against Candida spp. strains were evaluated. Compound 1 presented strong antimicrobial action for C. krusei with MIC of 15.6 µg/mL, activities against strains of C. albicans (62.5 µg/mL), and C. tropicalis (125.0 µg/mL). In addition, it was evidenced that biological activity occurs in the plasma membrane in C. albicans. The results of the in silico study showed that the predicted inhibition of HSP90 and aldehyde dehydrogenase could explain the antifungal activity of Compound 1. New derivatives can be synthesized from the functionalization of these chemical structures and may result in more potent antifungal compounds, in addition to advancing the investigation of the mechanism of action. Therefore, the data highlight the potential of these compounds in the search for antimicrobial drugs.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202403459

Authors: Jeremias Justo Emídio, David Henrique Xavier Barbosa, Ricardo Dias de Castro, Yunierkis Perez‐Castillo, Damião Pergentino de Sousa

Institutions: Universidade Federal da Paraíba, Universidad de Las Américas

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico