Work

First demonstration of implication of hereditary alpha-tryptasemia in vasospastic angina: a case report

Year: 2025

Type: article

Abstract: Background: Vasospastic angina is a common condition. In cases of poor therapeutic response, less common causes should be explored. Case summary: A 50-year-old woman with vasospastic angina was diagnosed with significant fluctuation in response to treatment without explanation that led to the suspicion of an allergic phenomenon. A diagnosis of hereditary alpha-tryptasaemia was made, and introduction of a second-generation H1-antihistamine has enabled effective control of previously treatment-resistant vasospastic coronary disease. Discussion: The case shows the first time the involvement of hereditary alpha-tryptasaemia in vasospastic angina. Future pathophysiological investigations will be needed to further explore the connection between these two pathologies.

Source: European Heart Journal - Case Reports

DOI: 10.1093/ehjcr/ytaf130

Authors: Benoit Caullery, Alexis Bocquet, Laurent Riou, Gilles Barone-Rochette

Institutions: Centre Hospitalier Universitaire de Grenoble, Inserm, Université Grenoble Alpes, French Clinical Research Infrastructure Network

Language: English

Topic: Mast cells and histamine

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $815