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Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays

Year: 2025

Type: article

Abstract: Despite global efforts, antimicrobial resistance persists. Mechanisms like heterotolerance further undermine antibiotic effectiveness. Testing > 1000 clinical strains revealed widespread heterotolerance largely missed by conventional MIC-based diagnostics. Since AMR alone does not predict treatment success, new tests and strategies incorporating tolerance data are urgently needed to significantly improve patient outcomes.

Source: Drug Resistance Updates

DOI: 10.1016/j.drup.2025.101239

Authors: Bram Van den Bergh, Philip Ruelens, Lieze Agten, Laurence Van Moll, Nele Geerts, Laure Verstraete, Sang Nguyen, Linda De Vooght, Natalie Verstraeten, Paul Cos, Jan Michiels

Institutions: Vlaams Instituut voor Biotechnologie, VIB-KU Leuven Center for Microbiology, KU Leuven, University of Antwerp

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,410

Funders: Fonds Wetenschappelijk Onderzoek, KU Leuven, Onderzoeksraad, KU Leuven, Vlaams Instituut voor Biotechnologie

Awards: Biology and ecology of bacterial and fungal biofilms in humans., G3142847620, PersiSTRESS: How the stress-resistance antiporter GadC integrates bacterial osmoregulation and pH homeostasis with antibiotic-tolerant persistence, In vivo multidrug-tolerant persister cells and their evolution in the face of antibiotic treatment: genetic and physiological adaptation mechanisms, Biology and ecology of bacterial and fungal biofilms in humans., G6240194965, G6677445941, Evolutionary trajectories of antibiotic susceptibility in longitudinal bacterial isolates, Heterogeneity and speed of bacterial persister cell formation and awakening, G7396266856, Persistence in Streptococcus pneumoniae infections: elucidation of the importance of persister cells in chronic and recurrent infections, A combined in vitro and in vivo approach to unravel persister mechanisms in natural and clinical isolates of Pseudomonas aeruginosa

OpenAlex ID: W4408482579

FWCI: 0.704

Cites: 12

Cited by: 1

Related to: 10