Work

Impact of HLA alloimmunization in gene-modified autologous stem cell transplant for transfusion-dependent thalassemia

Year: 2025

Type: article

Abstract: ABSTRACT: We report our single-center experience demonstrating that HLA class I alloimmunization predicts longer time to platelet engraftment, increased bleeding complications, and higher transfusion requirements in patients undergoing gene-modified hematopoietic stem cell transplant for transfusion-dependent β thalassemia.

Source: Blood

DOI: 10.1182/blood.2024027034

Authors: Nora M. Gibson, Eugene Khandros, Caitlin W. Elgarten, Elizabeth Worster, Dimitrios S. Monos, Alexis A. Thompson, Janet L. Kwiatkowski, Timothy S. Olson

Institutions: Children's Hospital of Philadelphia, University of Pennsylvania

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4408492560

FWCI: 5.23

Cites: 14

Cited by: 8

Related to: 10