Work

Triple synchronous primary cancers comprising large cell neuroendocrine carcinoma of the lower uterine segment and endometrioid carcinomas of the uterine corpus and the right ovary-a rare combination: A case report

Year: 2025

Type: article

Abstract: We report a rare case of triple primary cancers in a 52-year-old woman who presented with abdominal pain and fever. Diagnostic imaging and subsequent histopathological evaluation revealed independent primary endometrioid carcinomas of the ovary and uterine corpus proper (UC), as well as large cell neuroendocrine carcinoma (LCNEC) originating from the lower uterine segment (LUS). Surgical resection was performed, followed by adjuvant chemotherapy (irinotecan and cisplatin). The patient demonstrated no recurrence at the 10-month follow-up. This case highlights the importance of accurate pathological differentiation, as prognosis and treatment depend on distinguishing independent primary tumors from metastatic lesions. This rare case of triple synchronous malignancies emphasizes the need for a multidisciplinary approach to ensure precise diagnosis and optimal management. Comprehensive molecular studies and advanced imaging techniques may further improve outcomes in such complex cases.

Source: Gynecologic Oncology Reports

DOI: 10.1016/j.gore.2025.101721

Authors: Kaichiro Yamamoto, Shin-ichi Nakatsuka, Tomochika Goto, Reiko Samoto, Aki Minami, Masatoshi Imamura

Institution: Yao Tokushukai General Hospital

Language: English

Topic: Multiple and Secondary Primary Cancers

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $930