Extracellular Vesicles Delivered by a Nanofiber‐Hydrogel Composite Enhance Healing In Vivo in a Model of Crohn's Disease Perianal Fistula (Adv. Healthcare Mater. 7/2025)
Year: 2025
Type: article
Abstract: Crohn's Disease Perianal fistulas in Crohn's disease (CD) face high treatment failure rates despite surgical advances. The article 2402292, Hai-Quan Mao, Florin M. Selaru, and co-workers introduce an injectable nanofiber-hydrogel composite (NHC) delivering mesenchymal stem cell-derived extracellular vesicles (EVs) to treat CD perianal fistula in a rat model. The EV-NHC demonstrated superior healing and reduced inflammation via sustained EV release, macrophage polarization, and neo-vascularization, offering a promising clinical translation pathway.
Source: Advanced Healthcare Materials
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4408501224