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White Blood Cell Count Is Associated with Hyperuricemia in Patients with Type 2 Diabetes Mellitus

Year: 2025

Type: article

Abstract: Background: Hyperuricemia is highly prevalent among patients with type 2 diabetes mellitus (T2DM). Inflammation is associated with the process of hyperuricemia. However, it is unclear whether white blood cell (WBC) count, a convenient inflammatory marker, is associated with hyperuricemia in patients with T2DM. Thus, we aimed to explore the possible association between WBC count and hyperuricemia in patients with T2DM. Methods: A total of 1768 patients with T2DM were retrospectively included. Cumulative data were analyzed in patients with T2DM. Results: /L, p<0.001). There was a significant positive correlation between WBC count and serum UA levels in patients with T2DM (r=0.165, 95% CI: [0.118, 0.211], p<0.001). Multivariable logistic regression analysis revealed an independent association between WBC count and hyperuricemia in patients with T2DM (OR=1.185, 95% CI: [1.077, 1.303], p<0.001). Conclusion: Elevated WBC count, even within the normal range, is associated with hyperuricemia in patients with T2DM, suggesting that chronic inflammation, as indicated by a higher WBC count, may be related to the development of hyperuricemia in patients with T2DM and urate-lowering therapy may be helpful to ameliorate chronic inflammatory damage in T2DM patients with hyperuricemia.

Source: Journal of Inflammation Research

DOI: 10.2147/jir.s501890

Authors: You-Fan Peng, Han Yin, Lin Hu, Li Fang, Dian-Rong Jia, Ling Li

Institutions: Affiliated Hospital of Youjiang Medical University for Nationalities, Zhongda Hospital Southeast University, Southeast University

Language: English

Topic: Gout, Hyperuricemia, Uric Acid

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836