Work

Mycobacterium heraklionense hand tenosynovitis—a case description of a three-year treatment course and perioperative measurement of azithromycin target tissue concentrations

Year: 2025

Type: article

Abstract: tenosynovitis case, we observed that azithromycin-loaded calcium sulfate beads placed in the surgical wound had minimal systemic absorption and achieved over 100-fold higher target tissue concentrations than a systemic azithromycin-based treatment regimen alone. However, continued excessive wound drainage necessitated surgical removal of the beads. While systemic antibiotics and surgery remain central to nontuberculous mycobacterial treatment, the role of local antibiotic administration in reducing the bacterial burden warrants further investigation.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01670-24

Authors: Mads Kristian Duborg Mikkelsen, Andrea René Jørgensen, Victor Naestholt Dahl, Christian Morberg Wejse, Mats Bue, Maiken Stilling

Institutions: Aarhus University, Aarhus University Hospital

Language: English

Topic: Mycobacterium research and diagnosis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Novo Nordisk, A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal, Novo Nordisk Fonden