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Connectivity Profile and Function of Uniquely Human Cortical Areas

Year: 2025
Type: article
Abstract: Quantitative comparison of the white matter organization of the human neocortex with that of the chimpanzee and macaque shows a wide distribution of areas with a uniquely human connectivity profile, including the frontal-parietal fiber systems and the temporal visual pathway. Functional decoding of these areas shows their involvement in language, abstract reasoning, and social information processing. Overall, these results counter models that assign primacy to prefrontal cortex for human uniqueness.
DOI: 10.1523/jneurosci.2017-24.2025
Authors: Katherine L. Bryant, Julia Camilleri, Shaun Warrington, Guilherme Blazquez Freches, Stamatios N. Sotiropoulos, Saad Jbabdi, Simon Eickhoff, Rogier B. Mars
Institutions: Aix-Marseille Université, John Radcliffe Hospital, University of Oxford, Wellcome Centre for Integrative Neuroimaging, Forschungszentrum Jülich, University of Nottingham, Radboud University Nijmegen, Donders Institute for Brain, Cognition and Behaviour, National Institute for Health and Care Research, Queen's Medical Centre, Nottingham Biomedical Research Centre, Heinrich Heine University Düsseldorf
Language: English
Field: Medicine
Open Access status: hybrid
Funders: Wellcome Trust, National Institutes of Health, Directorate for Biological Sciences, U.S. Fish and Wildlife Service, Biotechnology and Biological Sciences Research Council, Office of Research Infrastructure Programs, National Institutes of Health, H2020 European Research Council
Awards: The comparative connectome, G1704435659, G2115380233, G2453211753, G278379982, G3251738510, A cross-species, cross-modal approach to computational neuroanatomy, G5247183884, G651755458, G9000112919, G9000118633, G9000227440, G973358232
OpenAlex ID: W4408519656
FWCI: 11.64
Cites: 65
Cited by: 23
Related to: 10