Factors associated with elevated gentamicin trough levels in neonates: a retrospective analysis of dosing and clinical parameters
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: Investigate determinants of elevated gentamicin trough levels in neonates. Methods: This single-center retrospective analysis used a multivariate linear regression model to explore the relationship between gentamicin trough concentrations and factors such as creatinine levels, dosage, day of life, sex, CRP levels, and dosing interval in neonates. Results: In 215 neonates, including 68 (31.6%) premature neonates with a postmenstrual age of ≤35 weeks, shorter dosing intervals, higher creatinine levels, and increased dosage were linked to higher gentamicin trough levels. Elevated CRP levels corresponded with lower trough levels. Conclusion: This study highlights the critical role of dosing frequency, kidney function, and inflammatory status in influencing gentamicin trough levels in neonates. However, all gentamicin trough levels were within the 2 µg/ml threshold.
Source: Frontiers in Pediatrics
Institution: University Medical Center Hamburg-Eppendorf
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4408523543