IL-33 and ILC2 in pancreatic cancer: good, bad or a bit of both?
Year: 2025
Type: article
Abstract: Tertiary lymphoid structures (TLS) are associated with anticancer immunity, but the mechanisms underpinning their formation remain poorly understood. Amisaki et al. have recently shown that IL-33 mediates ILC2 gut-tumoral migration and promotes TLS formation in pancreatic ductal adenocarcinoma (PDAC) by inducing group 2 innate lymphoid cell (ILC2) Ltb expression. This study highlights new potential therapeutic avenues to enhance immunotherapy.
Source: Trends in cancer
Authors: Charlotte Simpson, Thomas Yip, Timotheus Y.F. Halim
Institution: University of Cambridge
Language: English
Topic: IL-33, ST2, and ILC Pathways
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $7,030
Funders: Pancreatic Cancer UK, Cancer Research UK
OpenAlex ID: W4408528425