Work

Electrochemical Synthesis of γ-Lactones from the Intermolecular Oxidative Coupling between Malonates and Styrenes

Year: 2025

Type: article

Abstract: We report a ferrocene-mediated electrochemical intermolecular oxidative annulation between malonates and styrenes that avoids the use of excess oxidants such as Mn(OAc) 3 . The reaction proceeds via presumably the generation of a malonyl radical that adds to the styrene. After further anodic oxidation, the resulting benzylic carbocation is intercepted by one of the esters to deliver the desired γ-lactones.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c00228

Authors: Antoine Lefevre, Régis Guillot, Cyrille Kouklovsky, Guillaume Vincent

Institutions: Centre National de la Recherche Scientifique, Université Paris-Saclay, Institut de Chimie Moléculaire et des Matériaux d'Orsay

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Agence Nationale de la Recherche, Centre National de la Recherche Scientifique, Université Paris-Saclay

Award: New developments in ELectrosynthesis and MulticomponEnt pRocesses