Effectiveness of Adjuvant Interferon Therapy (Alpha-2b Interferon) in Organ-Preserving (Photodestruction, Brachytherapy) Treatment of Uveal Melanoma
Year: 2025
Type: article
Abstract: Purpose: Consider the effectiveness of adjuvant interferonotherapy (IFT) in patients with choroidal melanoma (CM) in combination with xenon photocoagulation (XP), transpupillary thermotherapy (TTT), brachytherapy (BT). Methods:The analysis was carried out in 702 patients with MS (men -317 (51.7±0.15)patients, women -385 (53.1±0.13),who underwent treatment with XP, TTT, BT and IFTin various combinations.Results: It has been shown that IFT leads to a positive result in small swellings in 88.7%, in medium ones in 90.7%, in the control group in 64.0% and 76.2%, similar.There was no significant difference in the effectiveness of IFT with TTT or combined with BT.It was noted that in patients with partial tumor regression on the fourteenth day, with monitoring for 3 months.up to 3.5 years, the tumor regression was more active in the equal group, indicating an increase or stabilization of the tumor. Conclusions:The effectiveness of XP, TTT and their combination with BT in patients with ocular uveal melanoma (UM) in the significant world indicated by the clinical parameters of the tumor.The inclusion of interferon in the complex of XP and its combination with BT the process of tumor regression and improves the result for small tumor up to 88.7%, with average tumor up to 90.7%, in the control group 64.0% and 76.2%, similar.Depending on the clinical reaction of CM (resorption, stabilization, increase) on the 14th day after treatment, the sensitivity of tumor to treatment factors can be predicted and the result of outcome.
Source: JOJ Ophthalmology
Author: Anatoliy Maletskyy
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408535432