Work

Dynamic Alternations in Mother–Infant Dyad’s Gut Microbiota over the Period of Six Months

Year: 2025

Type: article

Abstract: Since birth, the human microbiome plays a pivotal role in health. It is intriguing to understand the establishing roles of intestinal microbiota in infants. This study aimed to investigate the dynamic changes in maternal and infant’s gut microbiota, the interaction between intestinal microbiota, and the function of intestinal microbiota. This study recruited one pregnant woman > 35 weeks gestational age. Faeces of the mother-infant dyad were regularly collected until six months of infant’s age for metagenomic analysis. The results showed the infant’s gut microbiota was different from the mother’s, majorly, encompassing Bacteroides fragilis, Ruminococcus gnavus, Klebsiella pneumoniae and Klebsiella michiganensis. Infant- or mother-specific differential metabolic pathways were found between the mother and infant’s gut microbiome, implicating differences in the intestinal metagenomic potential/function. In conclusion, the gut microbes and functions were gradually established as infant grew.

Source: Applied Sciences

DOI: 10.3390/app15063239

Authors: Lan Yang, Hafiz Arbab Sakandar, Zhihong Sun, Heping Zhang

Institutions: Inner Mongolia Agricultural University, Ministry of Agriculture and Rural Affairs

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,896