Work

Dehydration-induced AVP stimulates glucagon release and ketogenesis

Year: 2025

Type: article

Abstract: Gliflozin-induced ketogenic effects partly result from increased glucagon levels. This study shows that dapagliflozin-triggered glucagon secretion is not directly mediated by the pancreas but rather linked to arginine-vasopressin (AVP). Dehydration, common in diabetic ketoacidosis, elevates AVP, potentially explaining the increased ketoacidosis risk in gliflozin-treated patients. Thus, our results highlight AVP as a potential therapeutic target to mitigate the risk of ketoacidosis associated with gliflozin treatments in patients with diabetes.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00505.2024

Authors: Thomas G. Hill, Linford J. B. Briant, Angela Kim, Yanling Wu, Patrik Rorsman, Ingrid Wernstedt Asterholm, Anna Benrick

Institutions: University of Oxford, Beth Israel Deaconess Medical Center, Harvard University, University of Gothenburg, University of Skövde

Language: English

Topic: Diabetes Treatment and Management

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Wellcome Trust, Svenska Forskningsrådet Formas, Vetenskapsrådet, Stiftelsen Mary von Sydows, född Wijk, donationsfond, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G2125805635, Obesity and androgen excess in women; Adiponectin as a new treatment for metabolic, reproductive and mood disorders, Collagen-degrading macrophages in subcutaneous adipose tissue expansion, G8586585743, Recruitment of Professor Patrik Rorsman and the establishment of a "metabolic physiology" unit at the University of Goteborg, G9000061707

OpenAlex ID: W4408550543

FWCI: 0.591

Cites: 96

Cited by: 1

Related to: 10