Hyperbaric Oxygen Therapy for Patients With Viral or Radiation-Induced Hemorrhagic Cystitis
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Hemorrhagic cystitis (HC) is characterized by diffuse inflammation and bleeding of the lining of the urinary bladder. This study investigated hyperbaric oxygen therapy (HBOT) in patients with viral or radiation-induced HC. METHODS: A retrospective analysis was performed involving 33 patients diagnosed with HC who received HBOT. Data analysis involved the Kruskal-Wallis test and Spearman's correlation coefficients to determine the strength of correlations between variables. RESULTS: Of the 33 patients, nine (27.3%) had radiation-induced HC, and 24 (72.7%) had viral HC. Among those with viral HC, 12 (50%) tested positive for BK virus by polymerase chain reaction (PCR). HBOT was performed in a multiplace hyperbaric chamber at 2.5 absolute atmospheres (ATA) for 90 to 120 minutes, and the median number of sessions was 11. The median duration of treatment was 14 days, with 81.8% (n = 27) obtaining an improvement in macroscopic hematuria, 12.1% (n = 4) interrupting treatment, and 6.1% (n = 2) dying. HC did not recur in 57.6% of the sample (n = 19) in three years of follow-up. A significant correlation was found between the degree of hematuria and the number of sessions required (p = 0.0025). Radiation-induced HC was associated with higher degrees of hematuria (p = 0.007). A correlation was found between etiology and recurrence after the conclusion of treatment (p = 0.029). CONCLUSION: Identifying the cause of HC and classifying the degree of hematuria are important to planning the number of HBOT sessions needed for an improvement in symptoms and a reduction in the rate of recurrence after treatment. The present findings suggest clinical benefits from HBOT in the treatment of HC.
Source: Cureus
DOI: 10.7759/cureus.80755
Authors: Caiã Fraga Carvalho, Vincius C Lopes, Gabriel Agareno, Ana Clara Spessoto, Fernando Nestor Facio, Luís Cesar Fava Spessoto
Institution: Faculdade de Medicina de São José do Rio Preto
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408552946