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Multifocal Intestinal Extranodal Marginal Zone Lymphoma Presenting With Autoimmune Hemolytic Anemia: A Case Report

Year: 2025

Type: article

Abstract: Extranodal marginal zone lymphoma of the intestine is a rare, indolent non-Hodgkin lymphoma that often presents with nonspecific symptoms, making diagnosis challenging. We report a 74-year-old woman who presented with severe anemia attributable to autoimmune hemolytic anemia. Imaging revealed splenomegaly and intestinal wall thickening, whereas subsequent endoscopy showed ulcerated lesions in the ileocecal valve, transverse colon, and descending colon. Biopsy results confirmed extranodal marginal zone lymphoma. Treatment with the R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) regimen led to partial remission of the lymphoma and complete resolution of autoimmune hemolytic anemia.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2024.1222

Authors: Ali Emre Bardak, Naci Senkal, Kanan Nuriyev, Alpay Medetalibeyoglu

Institutions: St. Elizabeth's Medical Center, Istanbul University

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408558445

FWCI:

Cites: 10

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Related to: 10