Evaluation of virulicidal effect of biocidal agent on the resistance of parvovirus strain test
Year: 2025
Type: article
Abstract: The paper presents the results of a study of the virucidal efficacy of the biocidal agent "Tetrasept", the main active ingredients of which are glyoxalic aldehyde and glutaric aldehyde. The study was conducted in accordance with national and international guidelines for characterizing the virucidal properties of disinfectants. The toxicity of the biocidal agent "Tetrasept" was studied under conditions of protein loading in a rabbit kidney cell culture model (RK-13). The study of the virucidal efficacy of the biocidal agent "Tetrasept" was carried out under conditions of protein load on the model of the field strain of parvovirus "Antey". Toxicity and virucidal activity of "Tetrasept" were determined for working concentrations of 1.0%, 0.75%, 0.5%, 0.25%, 0.125% and 0.06%, 0.03% at exposure of 30 and 60 minutes, respectively. The results of the study showed that the biocidal agent "Tetrasept" is non-toxic to the transplanted cell cultures at concentrations of 0.125%, 0.06% and 0.03%, but has a weakly expressed virucidal effect. The disinfectant has 100% virucidal effect against the field strain of parvovirus at concentrations of 0.25% at exposure for 30 and 60 minutes at protein load, which indicates high virucidal activity of the biocidal agent "Tetrasept". Concentrations of 0.5 %, 0.75 % and 1.0 % have a toxic effect on cell culture.
Source: One Health Journal
Authors: V.L. Kovalenko, M.L. Radzikhovsky, O.V. Rudyi, J.M. Drozhe, A.P. Gerilovych, S.A. Ponomaryova, O.M. Stupak, O.O. Androshchuk, A.D. Grebinichenko
Institutions: State Scientific and Research Institute of Laboratory Diagnostics and Veterinary and Sanitary Expertise, National University of Life and Environmental Sciences of Ukraine, SCIVP of Veterinary Medicinal Products and Feed Additives, Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4408558480