Work

Association of chronic musculoskeletal pain, APOE Ɛ4 genotype, and analgesics with the risk of dementia: a population-based prospective cohort study

Year: 2025

Type: article

Abstract: Chronic musculoskeletal pain (CMP) is associated with the risk of dementia, yet little is known about whether this association is modified by APOE genotype and whether analgesics may mitigate the risk effect of CMP on dementia. This prospective cohort study, included 415 072 participants from UK Biobank, found that CMP was associated with a higher risk of dementia, and this association may be modified by the APOE genotype. Analgesics may not mitigate the risk effect of CMP on dementia.

Source: International Journal of Surgery

DOI: 10.1097/js9.0000000000002348

Authors: Yuan Zhang, Jiangtao Feng, Hongxi Yang, Shu Li

Institutions: Children's Hospital of Philadelphia, Tianjin Nankai Hospital, Tianjin Medical University, Tianjin University of Traditional Chinese Medicine

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,450