Decreases in H2A monoubiquitination in the amygdala constrain fear memory formation
Year: 2025
Type: preprint
Abstract: Evidence suggests a role for monoubiquitination of histone H2B, a regulator of increased gene transcription, in memory formation. However, whether monoubiquitination of histone H2A (H2Aubi), a transcriptional repressor, is involved in memory formation has not been explored. We found global and gene-specific decreases in H2Aubi in the amygdala following fear conditioning. H2Aubi decreased atPten, an inhibitor of PI3K–AKT–mTOR signaling, which occurred concurrently with increases in PTEN expression. CRISPR–dCas9 mediated upregulation of the H2Aubi ligase,Ring1b, in the amygdala enhanced contextual memory. These results suggest that decreases in transcriptionally repressive H2Aubi in the amygdala functions to constrain fear memory strength.
Source: Learning & Memory
Authors: Yeeun Bae, Harshini Venkat, Natalie Preveza, Meagan Turner, Timothy J. Jarome
Institution: Virginia Tech
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4408570847