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Antiproliferative Effects of Chlorogenic Acid Loaded Chitosan Nanoparticles: An In vitro Approach

Year: 2025

Type: article

Abstract: In recent years, chlorogenic acid has been reported to have multiple biochemical and pharmacological efficacy including anti-inflammatory and antioxidant properties. The poor solubility and low bioavailability are the major factors that reduce the therapeutic efficacy of the chlorogenic acid. The present study thus synthesized chlorogenic acid loaded chitosan nanoparticles (CACNP) using ion gelation procedure and evaluated its antiproliferative effect against Hep-2 cells under In vitro condition. MTT assay, ROS generation assay, MMP assay and Ao/EtBr assays are utilized to validate its antiproliferative potential in Hep-2 cells. CACNP significantly inhibited Hep-2 cell proliferation. The present study thus reveals the anticancer potential of CACNP, which open avenues for further research to assess its anticancer potential In vivo models.

Source: UTTAR PRADESH JOURNAL OF ZOOLOGY

DOI: 10.56557/upjoz/2025/v46i74862

Authors: Jawahar Monsi@Thara, Shanmugam Manoharan, Govinthan Alagumanivasagam, Shanmugam M Sivasankaran, Azhamuthu Theerthu

Institution: Annamalai University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408586936

FWCI:

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