Dentin Sialophosphoprotein Expression Profile in Developing Human Primary Teeth: An Experimental Study.
Year: 2025
Type: article
Abstract: Statement of the Problem: Tooth development is initiated by localized thickenings of the primary epithelial bands. Dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in the dentin matrix. DSPP's expression extends to multiple tissues, including dentin, cementum, and bone. However, the role of DSPP is not yet clear in the development of human tooth. Purpose: The current study aimed to examine the DSPP expression profile during the development of human primary tooth structures with a sufficiently large sample size. Materials and Method: < 0.05). Results: An increase in DSPP expression was observed with the progression of gestational weeks in different histological structures of developing human primary teeth. Conclusion: An increase in the expression level of DSPP with the progression of gestational weeks may confirm that reciprocal interactions between the enamel organ (EO) and dental pulp cells contribute to tooth formation.
Source: PubMed
Institutions: Hamedan University of Medical Sciences, Griffith University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4408588414