Work

Synchronous colonic metastasis of sarcomatoid chromophobe renal cell carcinoma. Diagnostic challenges and value of CD10 and vimentin immunostains in diagnosis

Year: 2025

Type: article

Abstract: In chromophobe renal cell carcinoma (CRCC), sarcomatoid and rhabdoid features denote a dismal prognosis, a short time to recurrence, and metastatic disease after nephrectomy. A 58-year-old male presented for management of a septic shock secondary to stercoral peritonitis. Four months before, he underwent a right nephrectomy for a lower polar renal tumor. The final diagnosis concluded to a pT4 CRCC with extensive sarcomatoid and rhabdoid changes. An abdominal CT-scan objectified a heterogeneous colon mass without renal recurrence. Urgently, the patient underwent right hemicolectomy and segment-VI hepatectomy. Histology suggested high-grade sarcoma with undifferentiated tumor proliferation and a lack of well-differentiated epithelial component. Immunohistochemistry (IHC) confirmed the renal origin of the colon metastasis, which consisted solely of the dedifferentiated component of CRCC. Tumors originating from the kidney should be considered in the differential diagnosis of undifferentiated colorectal cancers. An excellent anatomo-clinical correlation and a suitable IHC workup would reveal the appropriate diagnosis.

Source: Journal of Surgical Case Reports

DOI: 10.1093/jscr/rjaf145

Authors: Kenza Oqbani, Ghassan El Omri, Amal Rami, Anass Idrissi

Institutions: Université Ibn Zohr, Université Mohammed VI des Sciences et de la Santé, Hôpital Universitaire International Cheikh Khalifa

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000